Scientist – Senior Scientist, DMPK

Who We Are

Cogent Biosciences is a publicly traded biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent’s lead therapeutic candidate, bezuclastinib (CGT9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis (SM), which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling. We are currently enrolling two Phase 2 clinical trials for patients with SM and a global Phase 3 trial for GIST patients.

This position works with a fast-paced team in Drug Discovery and Development to support DMPK activities such as providing quantitative bioanalysis, outsourcing in vitro ADME assays, and compiling in vitro and in vivo data for dissemination to the larger oncology team. The successful candidate will utilize their strong LC-MS skills and ADME/PK data to collaborate cross-functionally with in-house medicinal chemistry, pharmacology and toxicology teams and outside CROs.

Responsibilities

• Provide DMPK support to oncology project Lead and work across disciplines to advance small molecule oncology therapeutics toward the clinic.
• Support in-house in vivo bioanalysis and in vitro outsourcing of studies.
• Interpret bioanalytical and PK results and perform NCA PK modeling.
• Develop LC-MS/MS analytical methods to quantitate compounds and metabolites in biological fluids.
• Manage interactions with CROs as pertains to program team objectives.
• Conduct written and verbal scientific presentations to project teams with moderate independence.
• Good written and oral communication, including timely electronic laboratory notebook entries, group presentations and meeting administration.
• Proven work ethic, competence, enthusiasm, problem solving and team focus

Qualifications

• BS, MS or PhD in Drug Metabolism, Pharmaceutical Sciences, Toxicology, Pharmacokinetics, Pharmacology, Biochemistry, Biology, Chemistry or other relevant field.
• LC-MS bioanalysis in Pharma/Biotech - 6 years (BS), 4 years (MS), post-doc (PhD).
• One or more of the following: In vitro ADME, Spotfire, in vivo PK, LC-MS, bioanalysis and/or PK modeling.
• Prior collaborative work in a fast-paced environment with timely verbal and written communication.
• Strong knowledge of LC-MS/MS instrumentation, troubleshooting, method development and analysis of biological fluids, preferably on Sciex QQQ platform.
• Independence, multi-tasking and organization.
• Adept at learning new software.
• MS Office Suite (Excel, Power Point, Word, etc).