Anil Bhushan

Dr. Anil Bhushan is the scientific founder of Deciduous where his lab was one of the first to show the role of clearing senescent cells in models of Type 1 diabetes. The long-term goal of his research is to understand the role of tissue secretory senescent cells in aging, autoimmunity and metabolic diseases. Recently they showed that pancreatic beta cells acquire a secretome in T1D in both mice and humans and exhibit many non-cell autonomous properties. Subsequently they have identified key immune cells that can selectively eliminate senescent beta cells to halt progression of beta cell destruction to prevent T1D in mouse models. They now utilize immune modulatory targets to identify new drugs that specifically eliminate secretory senescent cells in humans.