DICE Therapeutics
Tim joined DICE Therapeutics as the Chief Medical Officer in August 2020. Prior to DICE, Tim was a Senior Medical Director at Genentech in the OMNI early clinical development group. At Genentech, Tim served as the disease area expert in inflammatory bowel diseases where we he led efforts in the development of therapeutics in inflammatory bowel disease including the Phase 2 studies of the anti-integrin, etrolizumab, and an IL-22Fc fusion protein in ulcerative colitis. Tim also led the Phase 2 program of the BTK inhibitor, fenebrutinib, in chronic spontaneous urticaria. In addition to these clinical programs, Tim also co-led efforts to understand the potential role of the microbiome in IBD as well as the utility of magnetic resonance enterography as a tool for clinical development in Crohn’s disease.
Prior to Genentech, Tim was at UCSF where he was an internal medicine resident, gastroenterology fellow, postdoctoral fellow, and assistant adjunct professor. Tim holds an M.D., Ph.D. degree from the University of Texas Southwestern Medical Center and B.S. in biology from Yale University.
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DICE Therapeutics
At DICE Therapeutics, we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms. We believe that such pills will be widely appreciated by patients and doctors alike, as they provide a lower bar to entry than biologics, and as oral medicines can easily be co-formulated with other efficacious drugs. The combination of our core technology with additional, unique biophysical insights has enabled DICE to target protein-protein interactions with small molecules. In doing so, DICE has cracked open a previously intractable set of clinically validated therapeutic targets, including Interleukin-17 (IL-17). Our lead program – an orally bioavailable IL-17 antagonist for the treatment of psoriasis – is currently progressing through IND-enabling studies. In parallel, we continue to advance both partnered and internal pipeline drug discovery programs, providing a robust pre-clinical pipeline.