Prior to joining hc Bioscience, Dr. O’Neil was Director of Formulations at Codiak BioSciences, and worked as part of the CMC team developing programs in oncology/immuno-oncology, including exoIL-12™ and exoSTING™, and as CMC team leader for exoASO™-STAT6. At Codiak he also supported the manufacturing and quality teams in building a fit-for-purpose dedicated GMP exosome manufacturing facility. Prior to joining Codiak, he was head of formulations at Selecta Biosciences developing PLA/PLGA nanoparticle therapeutics. This included leading development of a novel transmission blocking malaria vaccine targeting the Pfs25 antigen with the Bill and Melinda Gates Foundation, and discovery of immunomodulatory formulations to induce tolerance to adeno-associated virus for repeat dosing without neutralizing anti-drug antibodies.
Dr. O’Neil completed his Ph.D. in Biomedical Engineering at the École Polytechnique Fédérale de Lausanne in Switzerland with a thesis focused on drug delivery applications of block copolymer self-assembling nanoparticles.
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