Dr Barnes investigates why the aged brain is vulnerable to neurodegeneration in order to identify strategies that may alleviate this susceptibility.
His group focuses on homeostatic neural plasticity processes which are thought to be critical for healthy network function. The group uses a combination of voltage and calcium imaging, bioelectronics and electrophysiology to determine the efficiency and mechanisms of homeostatic plasticity processes in both the aged brain and the early stages of neurodegeneration.
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