Scientist / Sr Scientist, Clinical Immunology

Scientist / Sr. Scientist, Clinical Immunology

Janux Therapeutics is seeking a highly motivated Scientist / Sr. Scientist with demonstrated skills in the field of cancer immunology and/or immune cell biology. The incumbent will develop, optimize, and qualify flow-based assays for clinical programs. Clinical samples may be run in-house or transferred to a CRO. This individual will assist in vendor management to ensure efficient assay transfer and running of samples to meet key deliverables. A successful candidate will have extensive hands-on experience with flow cytometry, T cell activation, assay development and optimization.

This position is approximately 25-50% hands-on bench work and requires the effective communication and documentation. The ideal applicant will be collaborative and team-oriented, self-motivated, possess excellent communication and organizational skills, and carry a strong commitment to excellence.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

These may include, but will not be limited to:

• Identify, develop, troubleshoot and/or execute flow-based assays for clinical programs (CRO or in-house)
• Draft and develop SOPs, qualification plans, and reports to support Janux programs
• Execute standard experiments evaluating T cell activation and cytotoxicity, as needed
• Interact closely with Research, Clinical, Biomarkers and QA teams to ensure activities are prioritized and deliverables are achieved in accordance with project timelines
• Manage CROs and maintain oversight on deliverables (timelines, experimental design, data analyses and reporting)
• Review controlled documents and study reports.
• Prepare and present data at relevant meetings.
• Help manage activities under tight timelines
• Keep up with published literature centered around cancer targets and immuno-oncology therapies directly relevant to Janux programs
• Other duties as deemed necessary

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

• PhD and 2+ years of relevant industry experience in immunology or immuno-oncology is preferred, or BS in a scientific discipline and a minimum of 5-10 years of experience; MS with a minimum of 4+ years related experience.

• Hands-on experience with development and qualification of multi-parameter flow cytometry (10+ colors) assays.

• Proficiency in phenotyping and culture of primary human immune cells (ie. PBMCs) is required.

• Proficiency in flow analysis is required (ie. FlowJo, DIVA, FCS Express, CellEngine, or Cytobank).

• Proficiency in excel, PowerPoint and GraphPad Prism is required.

• Excellent oral and written communication skills.

• Experience working with external vendors is a plus.

• Effective troubleshooting and problem-solving skills.

• Success in this role requires great attention to detail with the ability to multitask

• Skills to be an effective team player, strong individual contributor, self-motivated, flexible, and able to handle multiple tasks and deliver high-quality results under tight timelines

• High organization skills and diligence with documentation is required

Compensation:

In addition to a competitive base salary ranging from $105,000 to $145,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus.  Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

Job Type: Full-time

Benefits:

• 401K

• Medical insurance

• Dental insurance

• Vision insurance

• Supplemental disability insurance plans

• Flexible schedule

• Life insurance

• Flexible vacation

• Sick time

• Incentive stock option plan

Schedule:

• Monday to Friday

Work authorization:

• United States (Required)

Additional Compensation:

• Annual targeted bonus %

Work Location:

• On site required – San Diego

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.