On July 13, 2020, Governor Tate Reeves named Chris Graham as Commissioner of the Mississippi Department of Revenue for a partial term ending in 2022. Governor Reeves reappointed Mr. Graham to a full six-year term in 2022. The Mississippi Senate unanimously confirmed both appointments.

As Commissioner of Revenue, Graham works with a staff of over 600 employees who are responsible for collecting tax revenues that support state and local governments in Mississippi as well as titling and registration of motor vehicles, monitoring ad valorem assessments throughout the state, enforcement of Mississippi's Prohibition and Local Option Law, operating as the wholesale distributor of alcoholic beverages, and enforcement of Mississippi’s Medical Cannabis Act. He also serves as an ex-officio board member of the Mississippi Lottery Corporation and the Mississippi License Tag Commission.