Plectonic Biotech
Aron Baierlein is currently employed as a Working Student at Plectonic Biotech. Prior to this, they worked as a Tutor at Technical University of Munich for chemical lab courses for bachelor students. Aron also has experience as an Intern at Evonik in the Nutrition & Care GmbH department. They attained a Master of Science in Organic Chemistry from Technical University of Munich after completing a Bachelor of Science in Chemistry. Their educational background began at Werner-Heisenberg-Gymnasium where they obtained their Allgemeine Hochschulreife.
Plectonic Biotech
Antibody-based immunotherapies have great potential for the treatment of tumor diseases. However, an undesired over-stimulation of the immune system can lead to side effects that require the therapy to be discontinued. This overstimulation has two causes: First, the target antigens are often present both on the tumor tissue and on the healthy tissue. Secondly, the antibodies are active throughout the body and not only locally on the tumor. In order to solve these problems, we at Plectonic developed an "on/off button" for antibody immunotherapies. This is an ultra-miniaturized nanoswitch made of DNA. The nanoswitch can specifically recognize tumor cells and recruit the body's own immune cells to fight these cells. This enables the immune system to fight tumor cells in a targeted and "on demand" manner and leads to lower activity on healthy tissue and thus to fewer side effects. We term this new class of immunotherapeutics LOGIBODY - logic-gated antibody!