Scientist - MSAT

ABOUT US

At Quell we seek to deliver truly innovative, life-changing therapies for our patients. Our vision as a company is to build a major global biopharmaceutical company bringing transformational and valued therapies for a range of autoimmune and inflammatory diseases, as well as preventing rejection in organ transplantation, based on modular engineered Tregs.

OUR COMPANY

Quell Therapeutics Ltd (“Quell”), the world leader in the development of engineered T-regulatory (Treg) cell therapies for serious medical conditions driven by the immune system, announced it has raised $156 million in an oversubscribed Series B financing. The financing round was co-led by Jeito Capital, Ridgeback Capital Investments, SV Health Investors and Fidelity Management & Research Company LLC with participation from founding investor Syncona. New investors include British Patient Capital through its Future Fund: Breakthrough program, Janus Henderson Investors, Monashee Investment Management, Point72 and funds managed by Tekla Capital Management LLC

THE ROLE

We are looking to recruit a Scientist to expand our MSAT (Cell Process) team. A successful candidate will be working very closely with Process Development and GMP Manufacturing department within Manufacturing operations. The candidate will contribute to creation of the best ways of manufacturing process to help to develop our CAR-Treg therapies and will be involved in improving next generation products.

This position offers an excellent opportunity for a talented and motivated Scientist to contribute to a key part of our work. Quell offers an exciting and highly dynamic environment focused on developing cutting-edge Treg therapies.

MAIN RESPONSIBILITIES

• To provide technical expertise, and practical capacity to the MSAT (Cell Process) team
• Assist in designing, conducting, optimizing and evaluating new processes in manufacture within GMP environment
• Manage MSAT related activities across multiple projects and providing technical leadership for completing projects with minimal supervision.
• Maintain highly organised and detailed documentation and establishing relevant SOPs.
• Collaborate and coordinate work with other teams to meet deadlines and goals.
• Manage and support external collaborations as a subject matter expert in immunology.
• Support Tech transfer activities both internal and external facilities.
• Support root cause analysis and assessing non-product quality impacting deviations.
• Authors and reviews batch records, bill of materials and change controls.  Assesses change controls for impact of any change to the process, equipment, or procedures.

EXPERIENCE

• Practical experience implementing design of experiments to develop processes
• Solid understanding of immunology and cell therapy.
• Demonstrable expertise in cell-based techniques include flow cytometry.
• Good understanding of working with quality management systems (e.g. Q-Pulse)
• Knowledge of tech transfer and working with CDMOs desirable.
• Previous experience working with GMP equipment

TECHNICAL REQUIREMENTS

•  Resourcefulness in overcoming challenges and possess the ability to thrive in a fast-paced environment.
• Ability to perform experiments independantly 
• Proven commitment to high quality work and maintenance of high standards.
• Contribute to a culture that embraces scientific excellence, integrity, urgency, patient centricity and continuous improvement.
• Ability to work collaboratively within a team, supporting one another and held accountable for project deliverables.
• Personal drive and goal orientation.
• Detail-orientated and accurate.
• Professional and personable communication skills.
• Driven to solve problems pragmatically.
• Demonstrates strong organisational and prioritisation skills to manage a diverse workload.
• Good working attitude, reliability, and flexibility.
• Desire to work with integrity and act as an ambassador for Quell and the wider business

EDUCATIONAL REQUIREMENTS 

•  BSc degree in a relevant study field and relevant industry experience. MSc beneficial