Sr. Research Associate I, Discovery Genome Editing

Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo
therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and
leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe
is overcoming the limitations of current genome editing technologies by developing custom engineered
enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for
CRISPR-based genetic medicine.

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop
the next generation of CRISPR-based therapeutics. The current role is for a Senior Research Associate
to advance our ongoing efforts to develop therapeutics for neurodegenerative disorders . The candidate
should have a passion for characterizing the CRISPR systems that advance our therapeutic programs.
The role will work collaboratively across interdisciplinary teams, including protein engineers, process
sciences, computational biologists, NGS, and disease experts. The candidate should bring experience in
molecular biology, cell culture, and a passion for creating tools to meet the challenge of this new frontier
in genetic medicine.

The candidate will have numerous opportunities for professional growth in a rapidly growing
biotechnology start-up, which includes growing into a role of increasing responsibilities and the ability to
publish highly impactful work in peer reviewed journals. 

Key Responsibilities:
● Work collaboratively and cross-functionally with other teams at Scribe to execute on projects with
established timelines.
● Plan, execute on in vitro and molecular biology assays. Analyze results and interpret data, to
provide conclusions to support research goals.
● Develop and implement protocols for in vitro cell assays to support screening.
● Effectively communicate scientific plans and progress to stakeholders, verbally and in writing.
● Maintain rigorous data traceability.
● Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science
Required Skills and Background:
● A Bachelor’s and/or Masters in Neuroscience, Molecular & Cell biology, Bioengineering,
Genetics, or related discipline with 3+ years (Msc) or 5+ years experience (Bsc) relevant
experience.
● Hands-on experience analyzing DNA/RNAs methods or proteins (ELISA, qPCR, ddPCR, flow
cytometry, western blot, and other techniques). Method development experience with ddPCR is
highly valued.

● High level of proficiency in molecular biology techniques, including molecular cloning (gibson,,
processing genomic DNA/RNA, and imaging related techniques (IHC/IF staining, confocal
microscopy)
● Strong mammalian cell culture experience ( primary, immortalized cell lines). Direct experience
with neuronal lines (iPSC-derived neurons or other) is a plus.
● Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research
team.
● Excellent prioritization and organization skills
Preferred Skills and Background:
● Competence with viral and non-viral based payload delivery modalities (AAV, Lentivirus, mRNA
lipofection).
● Direct experience in the development of gene and/or cell therapy-based treatments for
CNS/neuromuscular disorders
● Experience with high throughput or high content assays for screening is desirable.
● Familiarity with CRISPR-Cas gene editing systems
● Previous industry experience

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and
fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to
hear from you! Visit us at www.scribetx.com.  

We are committed to creating a diverse environment and are proud to be an equal opportunity employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion,
gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or
veteran status.

At the time of posting, the base pay wage range for this role is $85,000-$130,000 per year. The offered
pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications,
training, and market data. Additional incentives are provided as part of the complete package in addition
to comprehensive medical and other benefits.