Associate Scientist, Protein Science

THE COMPANY

Septerna is an early-stage biotechnology company with a vision to become the industry-leading G protein-coupled receptor (GPCR)-focused R&D company with a portfolio of life-changing medicines. The company’s Native Complex™ Platform recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular environment to enable new technologies for industrial-scale drug discovery for the entire GPCR target class for the first time. Septerna has an emerging pipeline of GPCR-targeted small molecule drug discovery programs, along with growth potential to reach many GPCRs that have been undruggable and unexploited to date. Septerna was launched by scientific founders who have made groundbreaking GPCR discoveries and by founding investor Third Rock Ventures. For more information see: www.septerna.com.

Join a multidisciplinary team of colleagues focused on creating revolutionary medicines to address significant needs of patients. Bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to our mission. At Septerna we embrace diversity of thought, expertise, and background; we share a fearless pursuit of ground-breaking innovations; and our employees learn from each other and succeed as a team.

THE ROLE

We are seeking passionate and creative individuals who want to contribute to Septerna’s mission to utilize innovative drug discovery technologies for GPCR targets. The ideal candidate will have a strong background in protein biochemistry, protein expression, purification, and characterization, along with experience in mammalian and bacterial cell culture.

The chosen candidate will be working in a collaborative team contributing to workflows for the production and characterization of proteins, structural biology, and the development, validation and implementation of biochemical assays. This position offers the unique opportunity to join an innovative well-funded startup and to contribute to its long-term success.

RESPONSIBILITIES

• Design and implement workflows to express, purify and characterize proteins form mammalian, bacterial, and insect cells.
• Responsibilities will include molecular biology, mammalian tissue culture, generation and validation of baculovirus, ELISA, and automated column chromatography (FPLC/HPLC)
• Develop and perform cell-based and biochemical assays using a variety of readout technologies (e.g., fluorescence, luminescence, TR-FRET, AlphaLISA, radioligand binding, etc.)
• Work in a collaborative environment to support discovery and structural biology efforts for internal drug discovery programs
• Independently design, execute, and interpret biochemical workflows
• Data analysis, documentation, and presentation in group and project team meetings

QUALIFICATIONS

• B.S. or M.S. in Protein Biochemistry, Molecular Biology, Bioengineering or other related disciplines is required
• Minimum of 4+ years of research in an academic, biotechnology, or pharmaceutical setting
• Proficiency in molecular biology, cell culture, and protein expression in bacterial, insect, and mammalian systems
• Experience in using automated column chromatography (FPLC) – size exclusion, ion-exchange, etc.
• Experience with automation and data analysis/reporting software is highly desired
• Demonstrated experience building strong partnerships across the organization; ability to work collaboratively in a team-oriented environment while also working independently on experimental planning, data analysis and interpretation
• Clear and effective verbal and written communication skills

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.