Daniel I. Simon

Daniel I. Simon, MD, is President of Academic & External Affairs and Chief Scientific Officer for the University Hospitals Health System (UH).

As President of Academic & External Affairs and Chief Scientific Officer, Dr. Simon leads the system’s strategy and performance across the spectrum of research including basic, translational, clinical and health services/outcomes. UH is home to some of the most prestigious clinical and research programs in the nation, with a total research portfolio, in conjunction with Case Western Reserve University, of $180 million and more than 2,500 active clinical trials and research studies underway.

He also oversees UH’s graduate medical education and has primary responsibility for academic affiliations, including with Case Western Reserve University, Oxford University, NEOMED and Technion – Israel Institute of Technology. Dr. Simon is also charged with elevating the system’s performance in medical education and discovery to the highest levels and driving strategic philanthropy.

Additionally, Dr. Simon oversees the Harrington Discovery Institute at University Hospitals -- part of The Harrington Project for Discovery & Development and has executive leadership responsibility for the Office of Community Impact, Equity, Diversity and Inclusion.

Since joining UH in 2006 as Division Chief of Cardiovascular Medicine at UH Cleveland Medical Center and as Director of the UH Harrington Heart & Vascular Institute, Dr. Simon has been promoted to increasing levels of responsibility as the system has grown, including President of UH Cleveland Medical Center, President of Community Medical Centers, and Chief Clinical & Scientific Officer for the entire health system.

Dr. Simon is a practicing cardiologist and continues to play a leading role in national and international clinical trials investigating new devices and anti-thrombotic drugs.

Prior to UH, Dr. Simon served as Associate Director of Interventional Cardiology at Brigham and Women’s Hospital in Boston and was an Associate Professor of Medicine at Harvard Medical School.

A recipient of numerous research awards, Dr. Simon was elected into the American Society for Clinical Investigation, Association of University Cardiologists, and the Association of American Physicians. He is a recipient of the prestigious MERIT Award from the National Heart, Lung, and Blood Institute and the 2016 Distinguished Scientist Award from the American College of Cardiology. He is a Fellow of the American College of Cardiology, the American Heart Association, and the Society of Cardiac Angiography and Interventions.

He has published extensively in peer-reviewed basic science and clinical journals. Dr. Simon has served on the Editorial Boards of Circulation and Journal American College Cardiology and is currently appointed to the Editorial Board of JAMA Cardiology.

He graduated summa cum laude from Harvard College. After earning his medical degree from Harvard Medical School, he completed his internal medicine residency and cardiovascular medicine fellowship at Brigham and Women’s Hospital and interventional cardiology training at Beth Israel Hospital, Harvard Medical School.

Dr. Simon is the Co-Founder of Sujana Biotech, a start-up biotechnology company developing novel monoclonal antibodies for a range of inflammatory and vascular disorders. The company’s lead product is in the early preclinical phase of development.

Dr. Simon serves on the Board of Directors of Playhouse Square and University Circle Inc.