Manasi Sinha Jaiman

Dr. Jaiman has significant expertise in both drug and device development, especially for diabetes. Prior to ViaCyte, Dr. Jaiman was Senior Medical Director at Covance Clinical Development Services. She was also an attending physician at Harvard Medical School and Massachusetts General Hospital, where she was responsible for clinical care of type 1 and type 2 diabetes pediatric patients at Massachusetts General Hospital. Before joining Covance, she was involved in a variety of diabetes-related and obesity-related clinical research activities. In particular, she served as pediatric lead for three major clinical trials and co-investigator for 10 adult trials, evaluating improvements in glycemic control using a bihormonal, dual-chambered “bionic pancreas” programmed to deliver insulin and glucagon in response to real-time glucose sensor monitoring data. She was also a co-investigator in the development of a stable glucagon formulation using hyperinsulinemic-normoglycemic clamp techniques. Other research contributions included development of intradermal delivery of insulin and glucagon using a novel microneedle device, metabolic effects of gastric bypass surgery in young patients, and pharmacokinetic studies on multiple insulin types. Dr. Jaiman received her M.D. from Medical University of South Carolina and M.P.H. from Tulane University School of Public Health and Tropical Medicine. She completed her pediatric residency at Dartmouth-Hitchcock Medical Center and endocrinology fellowship at Massachusetts General Hospital, with a focus on type 1 diabetes research.