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Senior Scientist I, Analytical Development (bioassays)

San Francisco, United States

Job description

Vir Biotechnology is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes infectious disease programs for chronic hepatitis delta and chronic hepatitis B infections and multiple dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give their best, we will collectively deliver outstanding results.

THE OPPORTUNITY

Vir Biotechnology is looking for a Senior Scientist I to lead development of bioassays to interrogate the mechanism of action for T Cell engagers and other biologic therapeutics. You will design and execute cell-based activity, target binding, and reporter gene assays for characterization testing in support of product, process and formulation development, and comparability and structure-activity relationship studies. You will develop new methods, optimize, and qualify a selection of methods according to regulatory and phase appropriate requirements. You will design and conduct laboratory experiments, author protocols/reports, and serve as the subject matter expert (SME) for bioassays on cross-functional teams.

This role is located in our San Francisco headquarters with an expectation of 4 days per week in office.

You will report to the Director of Analytical Development Bioassays.

WHAT YOU'LL DO

  • Develop, qualify and transfer cell-based and binding bioassays and reporter gene assays
  • Bring in new assay modalities and technology to the group and collaborate with other analytical teams within Vir
  • Prepare assay standards, controls, critical reagents, and establish appropriate system suitability criteria
  • Perform characterization testing including binding assays (SPR, ELISA), reporter gene assays, and cell-based activity assays to support Process and Formulation development studies
  • Troubleshoot method-related issues internally and at external labs
  • Author study protocols, development/qualification reports and test methods, summarize and verify data for regulatory filings
  • Subject matter expert for Bioassays within the Product and Process Development department and the broader CMC organization

WHO YOU ARE AND WHAT YOU BRING

  • Bachelor's degree with 10+ years of industry experience, Master’s degree with 8+ years of industry experience, PhD with 5+ years of industry experience
  • Experience in bioassay method development, transfer and validation
  • Experience in T Cell biology, immunology, or related field
  • Experience in data analysis of bioassays including parallel line analysis and other statistical data analysis for evaluating method performance
  • Ability to execute laboratory experiments both independently and with other team members
  • Effective at trouble-shooting method-related issues at CDMOs and CROs
  • Experience working on multiple projects, adjusting quickly to changes in priorities
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WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $158,000 to $199,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other benefits and perks such as health, dental, vision, life and disability insurance benefits, non-accrual paid time off, company shut down for holidays, commuter benefits, childcare reimbursement, education reimbursement, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S.  We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Vir Biotechnology is an equal opportunity employer.  All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to race, color, religion, sex (including pregnancy), gender, gender identity, gender expression, sexual orientation, age, parental status, marital status, national origin, ancestry, disability, medical condition, genetic information (including family medical history), political affiliation, military service or any other legally protected characteristic. 

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.  Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful discrimination or harassment.

Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, participates in E-Verify.

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