Dr. Turner has, for over 25 years, led an NIH- and foundation-funded research program focused on gastrointestinal mucosal barrier function. The goals of this program are to understand the molecular mechanisms that build and maintain mucosal barriers to define the impact of barrier regulation and dysregulation on health and disease. His work has led to fundamental advances that have generated new paradigms of mucosal barrier regulation in gastrointestinal physiology and pathobiology. Turner’s group has built on these discoveries to develop novel, molecularly-targeted therapeutics that restore mucosal barrier function and shown that these agents can both prevent and treat experimental disease.