Senior Scientist/principal Scientist, Computational Chemistry

Frontier Medicines is seeking a highly motivated individual to fill the position of Senior Scientist / Principal Scientist, Computational Chemistry at the Boston site. The successful candidate will play a leading role in developing medicinal chemistry optimization strategies for our most important drug discovery campaigns. He/she will be reviewing experimental results and develop SAR hypotheses for activity, selectivity and properties, and make suggestions to improve the profiles of our leading small molecule drug candidates. As a covalent drug discovery focused company, there is the opportunity for method development for this evolving field besides using the full arsenal of existing ligand- and structure based methods and insights from unbiased machine learning type algorithms. In addition, the candidate will have the opportunity to provide project leadership by driving strategies and experimental designs outside the area of core expertise, manage external resources in structural biology, CADD and informatics, and mentor junior scientists.

This role is key to Frontier Medicines’ success and an opportunity to join and work in a highly collaborative and energetic team in a startup environment with short communication lines across functions and departments, and routine interactions with senior leaders. The position will report to the Head of CADD and an onsite role located in our Boston office.