Dmitry Gabrilovich

Dmitry Gabrilovich, M.D., Ph.D., is a thought leader in myeloid cell biology and serves as the Christopher M. Davis Professor in Cancer Research and Program Leader, Immunology, Microenvironment, and Metastasis at the Wistar Institute in Philadelphia and as the Wistar Professor at the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania. Dr. Gabrilovich was one of the discoverers of cells that are now called myeloid-derived suppressor cells (MDSCs), and his group characterized a number of molecular mechanisms regulating the expansion and function of these cells. He established the role of antigen-specific mechanisms of regulation of T-cell tolerance mediated by MDSCs and provided the first evidence that MDSCs can be therapeutically targeted in patients. His group also demonstrated that dendritic cells in tumor-bearing mice, as well as in cancer patients, are functionally impaired.