Senior Scientist I/ii (htp Screening)

OPPORTUNITY Mammoth Biosciences is seeking a Senior Scientist I/II within its Screening & Process Automation team to drive the development of cell-based screening workflows. The Screening & Process Automation team implements and maintains pooled and arrayed screening processes to accelerate progress across technology development and drug discovery projects. The successful candidate will focus on the development of semi-automated arrayed screening processes with human and mouse derived cell lines. Cross-team collaboration will be a central component of this role as the Senior Scientist will work closely with project scientists to define process specifications and validate process performance. This position will include opportunities for professional development and career advancement.

KEY RESPONSIBILITIES

• Workflow Scale-up: Take ownership of the scale up of a bench-scale workflow to high-throughput automated workflow
• Statistical Analysis: Conduct rigorous statistical analysis of all parameters of the process needed to define success including DOE and power analysis
• Experimentation: Execution of experiments to improve screening workflows through rigorous testing multiple parameters to identify conditions that maximize performance
• Reagent Production: Design and produce DNA and mRNA and cell-based reagents to perform arrayed transfections with diverse mammalian cell lines
• Training: Train colleagues to perform HTP screening workflows that have been developed
• Maintenance and Troubleshooting: Regular maintenance of performance of HTP screening workflows and troubleshooting when necessary
• Collaboration: Work closely across teams to reach the desired goal through problem-solving, teamwork, clear communication, and adaptability

REQUIRED QUALIFICATIONS

• PhD in Molecular Biology, Cell Biology, Biochemistry, Biomolecular Engineering or a related discipline
• Minimum of 3 years relevant professional experience in industry following completion of PhD or 8 years of professional experience for non-PhD candidates with a Bachelor's degree
• Hands-on experience in automated methods for high throughput evaluation of DNA- or mRNA-encoded proteins in human or mouse cell lines
• Demonstrated proficiency in applying statistical methods to experimental design and data analysis

PREFERRED QUALIFICATIONS

• 5 years of biotechnology industry experience
• 2 years of experience developing tools or workflows for (epi)genome editing applications
• Computer and scripting skills (Benchling, Geneious, JMP, SQL, R, Python, Prism)
• Experience with HTP mRNA production and screening in mammalian cell lines
• Experience with viral vector payload design, production and in vitro screening in mammalian cells

BENEFITS

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver and ergonomics benefits
• 401(k) with company matching