Margaret Wierman

Dr. Wierman received her medical degree and residency training at Baylor College of Medicine and her fellowship and research training at Massachusetts General Hospital and the Brigham and Women’s Hospital at Harvard University.

She has been a faculty member at the University of Colorado since 1987, and her expertise is in reproductive and neuroendocrinology. Dr. Wierman’s research interests are in the regulation of the genes that control the reproductive axis. She studies the mechanisms by which gonadal sex steroids and peptide hormones regulate the expression of the gonadotropin-releasing hormone (GnRH). The major goal of Dr. Wierman’s work is to define the mechanisms by which GnRH neuronal development is controlled in order to gain a deeper understanding of the pubertal process, infertility, and hypogonadism. The other focus of the lab is to understand the mechanisms of pituitary tumorigenesis. Translational studies are identifying new genes that cause or are markers of pituitary tumors. Both cellular and transgenic animal models, as well as human studies, are ongoing. Collaborative projects with other investigators at the University of Colorado Health Sciences Center (UCDHSC) include the role of sex hormones in body weight distribution at menopause and sex hormone effects on HIV transmission and progression in women.