Madeleine Cunningham

Dr. Cunningham is Co-founder and Chief Scientific Officer of Moleculera Labs. She is the George Lynn Cross Research Professor and the Presbyterian Health Foundation Presidential Professor and Microbiology and Immunology Director, Immunology Training Program University of Oklahoma Health Sciences Center. Dr. Cunningham’s laboratory has studied molecular mimicry, autoimmunity and infection related to inflammatory heart disease for the past 30 years. She has pioneered the development of human mAbs in understanding the pathogenesis of human diseases. Currently her laboratory is focused on translational studies of human diseases, to improve their diagnosis and treatment and determine how infections play a role in autoimmune diseases of the heart and brain. Dr. Cunningham is the director of an NIAID supported Immunology Training Program at the University of Oklahoma for the past 10 years. She has been the recipient of NHLBI Career Development and MERIT Awards and has been funded by NIH for the past 25 years. She is author of over 100 publications in peer-reviewed journals and speaks internationally on the findings of her research.

Dr. Cunningham’s laboratory studies the role of autoimmunity and infection in the pathogenesis of movement and behavioral disorders associated with streptococci, including Sydenham chorea, the neurologic manifestation of rheumatic fever, and pediatric autoimmune neurologic disorder associated with streptococci (PANDAS). Her laboratory identified antibody mediated neuronal cell signaling as the potential basis for choreic movement disorders. Other related movement and neuropsychiatric disorders such as obsessive compulsive disorder, Tourette’s Syndrome and Tics are under investigation to determine the presence and role of autoantibodies which may signal in the brain for these diseases.

View Dr. Cunningham’s lab at the University of Oklahoma which focuses on the investigation of molecular mimicry, autoimmunity, and infection.