Scientific Lead - Toxicty

Scientific Lead – Toxicity

London

Relation Therapeutics overview

At Relation Therapeutics, we pioneer approaches in large-scale machine learning and high-resolution biology to discover new drugs for patients with diseases of high unmet need. 

One of the core problems in drug discovery is understanding the biological mechanisms underlying disease. Our team combines single-cell profiling, biobank-scale genetics, experimental functional genomics, and end-to-end machine learning in order to decode and modulate the fundamental causes of ill health. We aim to transform drug discovery and development.

At Relation, we are committed to building diverse and inclusive teams. We are an equal opportunities employer and do not discriminate on the grounds of gender, sexual orientation, marital or civil partner status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability or age. We strive to create an interdisciplinary workplace that cultivates innovation through collaboration, and we empower each of our team members to do their best work and develop to their highest potential.

By joining Relation, you will be part of an exceptionally talented team, you’ll have extraordinary leverage to push the field of drug discovery, and you’ll help us shape our culture and strategic direction. Ultimately, your impact will be felt in patients’ lives.

Opportunity

Join our innovative Discovery team as a Scientific Lead – Toxicity and contribute to advancing preclinical development projects with a focus on on-target toxicity. We are seeking an experienced professional with expertise in preclinical development and the ability to address PK/PD questions. Your role involves leading projects, collaborating with experts, and providing strategic input on toxicity-related aspects. 

As a Scientific Lead at Relation, you will be a key member of our interdisciplinary team, collaborating with Wet-Lab Scientific teams, ML Scientists, Data Scientists, and other experts. Your role involves driving strategic priorities, contributing to the design and execution of drug discovery projects, and actively participating in cross-functional teams.

Our team is at the forefront of developing experimentally validated machine learning methodologies, transforming biobank-scale genetics data (from genotyping arrays to whole genome sequence) into actionable disease risk genes for drug discovery. Leveraging data from external biobanks like the UK Biobank (UKB) and our proprietary Osteomics clinical trial, we're unlocking new frontiers in genetics.

Role Responsibilities

• Lead and oversee preclinical development projects, with a specific focus on on-target toxicity.

• Address PK/PD questions, therapeutic window and provide strategic input to drive therapeutic projects forward.

• Collaborate with internal labs or external partners (CROs) to address toxicity-related challenges.

• Contribute creative input to projects, ensuring alignment with Relation's scientific standards and goals.

• Actively engage in scientific research, presenting findings at conferences and contributing to technical blogs.

Professionally, you have

• Ph.D. in immunology, biochemistry, medicinal chemistry or related field.
• Deep expertise in preclinical development, with a focus on on-target toxicity.
• Industry experience in preclinical development is essential.
• Ability to address PK/PD questions in the context of therapeutic projects.
• Strong communication skills, both written and verbal.
• Passion for making a positive impact on patients' lives through innovative preclinical development.

Personally, You Are

• An inclusive leader and a team player.

• A clear and effective communicator.

• Driven by the impact of preclinical development and addressing toxicity challenges.

• Motivated to stay at the forefront of scientific advancements.

• Passionate about contributing to meaningful advancements in healthcare.

Join us in this exciting role where you will have a direct impact on advancing our understanding of disease biology, supporting our mission to get transformative medicines to patients. Together, we're not just doing research; we're setting new standards in drug discovery. The patient is waiting!

Relation Therapeutics is a committed equal opportunities employer.