Principal Scientist, Medicinal Chemistry

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company has completed an initial public offering (IPO) in February of 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Essential Duties and responsibilities

• As a dynamic project leader, drive and direct medicinal chemistry functions for one or more drug discovery projects, working in concert with cross functional team members

• Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies

• Supervise and direct synthetic chemistry activities at contract research organizations (CROs)

• Serve as a scientific expert in medicinal chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities

REQUIREMENTS

The ideal candidate will have a strong synthetic and medicinal chemistry background with relevant experience working in a drug discovery environment.

• PhD in Organic or Medicinal Chemistry or its equivalent and 5-10 years industry experience in small molecule medicinal chemistry
• Demonstrated advancement of projects through various stages of drug discovery and delivery of clinical candidates
• Expert knowledge of modern methods of synthetic and medicinal chemistry
• Familiarity with structure-based drug discovery, experience of working closely with computational chemists as part of project team
• Track record of scientific contributions including peer reviewed publications, patent applications
• Highly motivated, results driven individual with excellent organizational, interpersonal and communication skills