Senior/principal Scientist – Bispecific/antibody Protein Engineer

                                                                          T-Cypher Bio

Senior/Principal Scientist – Bispecific/Antibody Protein Engineer

T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior or Principal Scientist with a strong background in bispecific or antibody protein production to advance our platform development as part of the Protein Engineering team.

What you will do

The primary focus of this role will be to execute experiments for the production, purification, screening & characterization of novel bispecific protein formats. The ideal candidate should have hands on experience with protein production and demonstrate a strong understanding of protein engineering and molecular biology-based methods.

Key Responsibilities

• Develop T cell receptors for clinical use in advanced modalities such as bispecific immune cell engagers, TCR-like antibodies or ADCs
• Drive the design, engineering, and characterization of TCR-based proteins using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches
• Produce, purify & characterize molecules, ensuring high purity and integrity for downstream assays
• Develop and optimize assays for the identification, characterization, and quantification of novel formats
• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects
• Analyse and record experimental results and communicate findings to the team and to management
• Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions
• Work in a fast-paced start-up environment, with the motivation to work on multiple projects in parallel.

To be successful you will need

• D. in Protein or Antibody Engineering, Molecular Biology, Protein Biochemistry, or a related field, plus a minimum of 5 years professional experience in protein research
• Demonstrated expertise in protein biochemistry, including experience in the production, purification, and characterization of proteins
• Hands on experience designing and producing antibodies, bispecifics or effector proteins
• Proven track record of working with recombinant protein expression systems, such as bacterial, yeast, or mammalian cell culture
• Strong expertise in protein engineering techniques, including rational design, library construction, and developable formats
• Desire to develop clinical antibody or soluble TCR-based therapeutic molecules
• Demonstrated expertise in basic molecular biology techniques including PCR, cloning, SDS-PAGE, mutagenesis and sequencing
• Desire to lead research projects whilst functioning as part of a wider research team
• Demonstrated ability of platform/protocol enhancements & improvements
• Ability to adapt to multiple roles in an evolving company
• Enjoy working towards challenging goals in a fast-moving environment
• Ability to follow and write protocols and SOPs
• Knowledge of health and safety regulations in a laboratory environment
• Strong organizational and communication skills (both written and verbal)
• Strong drive to deliver on company milestones and goals

What we offer

Competitive salary and benefits commensurate with qualifications and experience.

Modern, well-equipped office and laboratory facilities on Oxford Science Park.

Training and development opportunities in-line with the company’s goals and growth plans.

An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients’ lives.

How to apply

Applications will be evaluated in the order that they are received, you are encouraged to apply as soon as possible.

Applications will close once the position is filled.