Joe Bentz

Joe Bentz obtained his B.A. in Chemistry at Reed College (Portland, OR) and his Ph.D. in Biophysical Sciences at SUNY at Buffalo (Buffalo, NY). His research centers on using kinetics to analyze membrane protein function. Currently, he is focused on P-gp and other ABC transporters that have substrate overlap with P-gp, e.g. BCRP. This research has resulted in a new proposed paradigm for the kinetic modeling of this transport process and the molecular mechanism of P-gp mediated efflux. The kinetic model is directly applicable to all ABC transporters and is currently being incorporated into an in vivo PBPK model. In 2009, he was chosen to lead the kinetic analysis for the International Transport Consortium sponsored study involving 25 pharmaceutical companies on the usage of in vitro systems to predict clinically relevant drug-drug interactions, DDI. This study has culminated in several papers and in recommendations to the FDA for revisions to the in vitro criteria for requiring clinical DDI trials.