Meet the team

26 Companies Racing to Develop the Most Promising Coronavirus Vaccines and Drugs

By Anne Chou

Last updated: Feb 15, 2023

These 26 companies are working on some of the most talked-about coronavirus vaccines and treatments that are the furthest along in the development and clinical testing pipeline.

Gilead Sciences (Foster City, CA)

Type: Treatment (remdesivir), an antiviral drug

Stage: Several Phase 3 clinical trials started in March. Results are expected in the next few weeks

Additional information: Remdesivir, an antiviral drug that was developed as a drug to treat Ebola and other infectious diseases, is the furthest along of any potential treatment for COVID-19. It is being studied in several large-scale clinical trials in the U.S., U.K., China and other European countries.

Meet the team >

Fujifilm Toyama Chemical (Tokyo, Japan)

Type: Treatment (favipiravir), an antiviral drug

Stage: Phase 3 clinical trial started in early April in Japan. On April 9, the company announced a Phase 2 trial in the U.S.

Additional information: Avigan (generic name is favipiravir) was approved in Japan in 2014 as an influenza antiviral drug. Clinical trials of favipiravir in China showed that the drug was effective in treating COVID-19 patients, according to Chinese officials.

Meet the team >

Roche (Basel, Switzerland)

Type: Treatment (Actemra), an anti-inflammatory drug

Stage: Phase 3 clinical trials expected to start in April 2020 in different parts of the world, including the U.S.

Additional information: Actemra has been FDA-approved since 2010 to treat various types of arthritis. It also received FDA-approval in 2017 to treat cytokine release syndrome, a life-threatening immune response from certain cancer treatments. Researchers are studying Actemra to see if it could have a similar effect in taming the body’s immune response in severely ill COVID-19 patients. Roche received $25M from BARDA to accelerate its Phase 3 trial.

Meet the team >

Sanofi (Paris, France) and Regeneron Pharmaceuticals (Tarrytown, NY)

Type: Treatment (Kevzara), an anti-inflammatory drug

Stage: Phase 2/3 clinical trials started on March 30 in Italy, Spain, Germany, France, Japan, Canada and Russia, and on March 15 in the U.S.

Additional information: Kevzara, the FDA-approved rheumatoid arthritis drug made by Regeneron and Sanofi, could be used to calm an overactive immune response in the lungs seen in severely ill COVID-19 patients. Similar to Roche’s Actemra, Kevzara inhibits a key cytokine called IL-6. In a separate effort, Sanofi has teamed up with Translate Bio on a mRNA vaccine that they hope to have ready for clinical trials by the end of 2020 or early 2021.

Meet the Sanofi team and Regeneron team >

Novartis (Basel, Switzerland) and Incyte (Wilmington, DE)

Type: Treatment (Jakafi), an anti-inflammatory drug

Stage: Phase 3 clinical trial initiated on April 2; no start date announced yet

Additional information: Novartis and Incyte are evaluating the use of Jakafi, a JAK inhibitor, to treat a type of severe immune overreaction, called a cytokine storm, that can cause life-threatening respiratory complications in COVID-19 patients. Jakafi is FDA-approved to treat certain bone marrow disorders that that affect your body's ability to produce blood cells.

Meet the Novartis team and Incyte team >

Mesoblast (Melbourne, Australia)

Type: Treatment (remestemcel-L), an anti-inflammatory treatment

Stage: Phase 2/3 clinical trial initiated; no start date announced yet

Additional information: Mesoblast recently received FDA approval to run a randomized trial with NIIH researchers using its experimental stem cell treatment, remestemcel-L, for patients with acute respiratory distress syndrome due to COVID-19. The theory is that the stem cells could reduce inflammation and strengthen the immune system of COVID-19 patients.

Meet the team >

CytoDyn (Vancouver, WA)

Type: Treatment (leronlimab), an anti-inflammatory drug

Stage: Phase 2 clinical trial in the U.S. approved on March 31

Additional information: CytoDyn’s experimental drug, leronlimab, has shown promise as a treatment for patients with a certain type of metastatic breast cancer and HIV. The drug may work to calm the body’s immune response and potential over-response to the virus seen in COVID-19 patients.

Meet the team >

Apeiron Biologics (Vienna, Austria)

Type: Treatment (APN01), a dual action recombinant human ACE2

Stage: Phase 2 clinical trials were approved on April 2 to start in Austria, Germany and Denmark

Additional information: Apeiron's drug candidate, APN01, can potentially block the novel coronavirus from entering cells and reduce lung injury, which is one of the most serious complications of COVID-19. It’s previously shown clinical trial success against other lung ailments such as ARDS and pulmonary arterial hypertension.

Meet the team >

Eli Lilly (Indianapolis, IN)

Type: Treatments - LY127804, a monoclonal antibody treatment, and baricitinib, an anti-inflammatory drug

Stage: Phase 2 clinical trials expected to start in late April 2020 in the U.S.

Additional information: Eli Lilly is advancing two drugs into clinical trials. Its experimental LY127804 treatment will be tested in COVID-19 patients who are at a higher risk of getting ARDS. Eli Lilly has also partnered with the NIH to study baricitinib, its FDA-approved rheumatoid arthritis drug, as a potential treatment for COVID-19 patients, and will begin its first trial in COVID-19 patients in the U.S. in late April.

Meet the team >

CanSino Biologics (Tianjin, China)

Type: Vaccine (Ad5-nCoV), adenovirus vector vaccine

Stage: Phase 2 clinical trial expected to start soon in China

Additional information: CanSino’s vaccine candidate is being developed with China’s Academy of Military Medical Sciences. CanSino said it is moving its vaccine from a Phase 1 to Phase 2 clinical trial after only 3 weeks. Its vaccine uses a common cold virus as a “vector” to deliver the gene for the coronavirus spike protein into cells to trigger an immune response.

Meet the team >

Moderna (Cambridge, MA)

Type: Vaccine (mRNA-1273), mRNA vaccine

Stage: Phase I clinical trials started on March 15 in the Seattle and Atlanta in collaboration with the U.S. NIAID

Additional information: Moderna became the first biopharma to start a human trial of an investigational vaccine against COVID-19, setting an industry record of 42 days to move from vaccine design to human testing. BARDA will collaborate with Moderna to prepare for Phase 2 and 3 clinical trials of the vaccine, with the hope of entering Phase 2 trials this spring or early summer.

Meet the team >

Inovio Pharmaceuticals (Plymouth Meeting, PA)

Type: Vaccine (INO-4800), DNA vaccine

Stage: Phase 1 clinical trials started on April 6 in the U.S.

Additional information: Inovio approach uses DNA-based technology to activate targeted immune responses that kill virus-infected cells. It has partnered with Beijing Advaccine Biotechnology on the development of its vaccine, and aims to produce one million doses of the vaccine by the end of 2020 for additional clinical trials or emergency use.

Meet the team >

BioNTech (Mainz, Germany) and Pfizer (New York, NY)

Type: Vaccine (BNT162), mRNA vaccine

Stage: Preclinical – Phase 1 clinical testing expected to start by late April 2020

Additional information: BioNTech signed a deal with Shanghai-based Fosun Pharmaceutical to co-develop its vaccine candidate BNT162 in China. On March 17, Pfizer announced it had teamed up with BioNTech to co-develop and distribute the vaccine outside of China.

Meet the BioNTech team and Pfizer team >

Novavax (Gaithersburg, MD)

Type: Vaccine (NVX-CoV2373), recombinant protein nanoparticle vaccine

Stage: Preclinical – Phase 1 clinical trial expected to start by mid-May in Australia. Results of the trial are expected around July 2020.

Additional information: In preclinical trials, NVX-CoV2373 was able to generate antibodies that could fight off the coronavirus that causes COVID-19. Novavax plans to combine its vaccine candidate with an adjuvant, a substance that enhances the effectiveness of vaccines, to boost immune response in humans.

Meet the team >

CureVac (Tübingen, Germany)

Type: Vaccine (mRNA vaccine)

Stage: Preclinical – Phase 1 clinical trials expected to start in June or July 2020 in Europe

Additional information: CureVac, a clinical stage biopharmaceutical company that specializes in mRNA-based drugs vaccines and therapeutics, has selected the best vaccine candidates in preclinical testing and expects to have a vaccine candidate ready for a Phase 1 clinical trial in early summer 2020.

Meet the team >

Regeneron Pharmaceuticals (Tarrytown, NY)

Type: Treatment (REGN3048-3051), monoclonal antibody treatment

Stage: Preclinical – Phase 1 clinical testing expected to start by the end of August 2020

Additional information: Regeneron said in March that it’s identified hundreds of virus-neutralizing antibodies from its genetically engineered mice and patients who have recovered from Covid-19, and will choose the best two with which to create a 'cocktail' treatment. The company used the same technology to develop a drug for the Ebola virus, which is under review by the FDA.

Meet the team >

Vir Biotechnology (San Francisco, CA) and GlaxoSmithKline (London, UK)

Type: Treatment ((VIR-7831 and VIR-7832), monoclonal antibody treatment

Stage: Preclinical – Phase 1 clinical trials expected to start in July – Sept. 2020

Additional information: Vir said two of its antibody drugs appear to be effective against the COVID-19. GSK announced on April 6 that it’s investing $250M in Vir and will collaborate on the development of potential antibody treatments for COVID-19. Vir has also partnered with Biogen, Chinese biotech company WuXi Biologics, and Alnylam Pharmaceuticals on coronavirus treatments.

Meet the Vir Biotechnology team and GlaxoSmithKline team>

Emergent BioSolutions (Gaithersburg, MD)

Type: Treatment (plasma-based treatment)

Stage: Preclinical – Phase 1 clinical trials expected to start this summer

Additional information: Emergent announced on March 11 that it’s working on two different plasma-based treatments (one using horse plasma and the other human plasma) using antibodies from recovered COVID-19 patients. The company announced on April 3 that it received $14.5M in federal funding from BARDA to speed the development of its treatment candidates.

Meet the team >

Johnson & Johnson (New Brunswick, NJ)

Type: Vaccine (adenovirus vector vaccine)

Stage: Preclinical – Phase 1 clinical trial expected to start by Sept. 2020 at the latest

Additional information: J&J’s subsidiary, Janssen Pharmaceutica, began developing its vaccine in February with BARDA support using the same vaccine platform used to develop its experimental vaccine for Ebola. On March 30, J&J announced a lead vaccine candidate. Its goal is to provide a global supply of more than one billion doses of its vaccine, with the first batches available for emergency use in early 2021. J&J said it’s committed to providing an affordable vaccine to the public on a not-for-profit basis.

Meet the team >

Pfizer (New York, NY)

Type: Treatment (Protease inhibitor antiviral drug)

Stage: Preclinical – Phase 1 clinical trial expected to start as early as August

Additional information: Pfizer announced on April 9 that it identified a lead coronavirus drug candidate, which research shows blocks the new corona virus from replicating. The findings so far indicate that the drug candidate could slow or stop the spread of the virus in COVID-19 patients with mild to moderate symptoms.

Meet the team >

Vaxart (San Francisco, CA)

Type: Vaccine (oral recombinant vaccine)

Stage: Preclinical - Phase 1 clinical trial expected to start early in the second half of 2020

Additional information: Vaxart is developing an oral recombinant vaccine that’s given by tablet rather than by injection. On March 31, Vaxart said it has produced five COVID-19 vaccine candidates for testing in its preclinical models, and expects to advance the best performing vaccine to manufacturing for clinical trials.

Meet the team >

Clover Biopharmaceuticals (Chengdu, China) and GlaxoSmithKline (London, UK)

Type: Vaccine (COVID-19 S-Trimer), recombinant protein subunit vaccine

Stage: Preclinical – data from collaborations over the next few months will be used to determine the next steps for clinical development of a vaccine candidate

Additional information: GSK announced a partnership on Feb. 24 with Chinese biotech firm Clover Biopharmaceuticals to combine GSK’s adjuvants with Clover’s protein-based COVID-19 vaccine candidate. Clover has also partnered with Berkeley, CA-based Dynavax Technologies in March to use Dynavax’s proprietary adjuvants to support development of Clover’s vaccine.

Meet the Clover Biopharmaceuticals team and GlaxoSmithKline team >

Amgen (Thousand Oaks, CA) and Adaptive Biotechnologies (Seattle, WA)

Type: Treatment (antibodies from recovered COVID-19 patients)

Stage: Preclinical

Additional information: The companies announced a partnership on April 2 to develop a therapeutic to prevent or treat COVID-19 on an accelerated basis. Adaptive will use its platform to screen blood samples from recovered COVID-19 patients to identity the specific antibodies that neutralize the novel coronavirus.

Meet the Amgen team and Adaptive Biotechnologies team >

Sources: The Wall Street Journal, The New York Times, The Washington Post, Bloomberg News, Stat News, Clinical Trials Arena, PhRMA, FiercePharma, FierceBiotech, Science, BioSpace, Contract Pharma and company press releases.

All data and statistics are based on publicly available sources as of April 12, 2020. Due to the unprecedented and rapidly changing nature of the coronavirus pandemic, some information may be out of date.

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