CA, United States
Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
We are seeking a highly skilled Senior Research Associate with extensive expertise in nucleic acid chemistry to join the sgRNA Drug Substance team within the Process Science department. The primary goal of this role is to develop, optimize, and implement early-stage Chemistry, Manufacturing, and Controls (CMC) capabilities for our lead pre-clinical candidates.
This position will involve close collaboration and study coordination with one or more R&D labs within the company as well as external collaborators and CDMOs, with a primary focus on advancing complex biologic therapies to human clinical studies and eventual licensure. As SRA – Oligonucleotide Chemistry, you will play a critical role as part of an expanding, cross-functional team to evaluate and apply emerging oligonucleotide chemistries and develop a deeper understanding of the interplay between sgRNA chemistry, RNP biochemistry and in vivo gene editing to unravel the underlying structure-function relationships between structurally complex sgRNA and RNPs. You will be required to develop additional competencies and apply practical skills and knowledge to solving a variety of applied scientific and technical problems.
Qualified candidates should have a minimum of 8 years of extensive, hands-on laboratory experience, of which at least 2 years will be in the synthetic DNA/RNA industry. A basic understanding of conventional solid-phase oligonucleotide synthesis and downstream processing such as cleavage and deprotection, filtration/ lyophilization, purification and analytical characterization is highly desirable. Multiple years of experience with sample prep, buffer prep and the routine operation and general maintenance of various HPLC systems is essential. The ideal candidate will also possess a good understanding of the underlying principles of HPLC-based techniques such as IP-RP, IEX, HIC, HILIC, SEC and subsequent data analysis (e.g., Agilent, AKTA, Vanquish and associated software). Candidate must have 2 or more years of experience operating, troubleshooting, and maintaining various LC-MS instruments and should be experienced with gel-based analysis of DNA, RNA or its conjugates using techniques such as capillary electrophoresis and PAGE. Previous experience working with enzymes, performing enzyme-based assays, purification and characterization of protein or RNP (affinity chromatography, SEC, SDS-PAGE) is highly desirable.
Candidates should be self-starters, strategic thinkers, action-driven, thrive in a fast-paced environment, excel at managing multiple priorities, and be capable of providing decision-enabling data.
Key Responsibilities:
Preferred Skills and Background:
Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.
At the time of posting, the base pay wage range for this role is $90,000-120,000 per year. The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data. Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.