Associate Director, Metabolic Disease Biology

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company has completed an initial public offering (IPO) in February of 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary

This Biology role will play a key role in advancing the metabolic research pipeline and driving biology directions of drug discovery projects, anchor muscle biology expertise and establish muscle biology related competencies, and be an essential part of interdisciplinary team and collaborate closely with cross-functional team members.

Essential Duties and responsibilities

• Study disease and target biology to evaluate new targets. Propose new projects.

• Establish muscle biology related competencies.

• Lead biology and drive discovery project to progress and achieve milestones

• Design and execute in vitro, in vivo and translational research to support target validation and drug candidate discovery. Ensure that experiments are performed to a consistently high standard

• Manage out-sourced studies with CROs and/or academic collaborators

• Responsible for data review, analysis and interpretation to enable program go/no-go decisions

• Work with research teams to manage multiple projects

• Support team members

• Interpret and present scientific findings at internal and external research meetings

• Collaborate and communicate across a diverse research team to progress scientific goals

REQUIREMENTS

• PhD in Biology or related field with at least 7 years of post-doctoral experience and 2+ years in industry
• Deep knowledge in muscle biology and metabolic diseases
• Experience in in vitro and animal models for muscle biology and metabolic diseases.
• Experience with translational science is a plus.
• Experience in discovering and validating drug targets and in progressing molecules into lead optimization. Experience in driving projects towards IND is preferred
• Excellent verbal and written communication skills with an ability to organize and communicate complex data sets in a clear and concise manner
• Demonstrated ability to work effectively in cross-functional team.
• Prior experience working at fast-paced biotech is preferred