Jacob Higgins

Jacob Higgins, Ph.D. has a diverse work experience in the scientific field. Jacob started their career at the University of Washington in 2004 as a Research Scientist, where they focused on mapping and sequencing candidate genes for various diseases. Jacob also played a key role in identifying genomic rearrangements and mutations in BRCA1 and BRCA2. In 2008, they joined the University of Michigan for their dissertation research, studying androgen receptor action during prostate cancer progression. Jacob utilized genetically engineered mice and human prostate cell lines to model different molecular subtypes of prostate cancer. Jacob then characterized the prostates and tumors through histology, immunostaining, RNA sequencing, and qRT-PCR analysis.

In 2017, Jacob started working at Fred Hutch as a Research Technician II. In this role, they used CRISPR to edit cell lines and generate reference material for single-cell analyses in leukemia and other cancers. Jacob addressed technical challenges such as false positives and allele dropout commonly observed in single-cell genotyping and sequencing approaches.

In 2017, Jacob also joined TwinStrand Biosciences, where they held multiple roles. Starting as an Industry Postdoc, they then progressed to Scientist I, Scientist II, and Senior Scientist. In these roles, they contributed to scientific research and applications, focusing on collaborative research projects. Jacob eventually became the Senior Scientist, Team Lead for Scientific Applications and Collaborative Research. Since November 2021, they have been serving as the Associate Director of Laboratory Research, overseeing research activities in the laboratory.

Overall, Jacob Higgins, Ph.D. has gained extensive experience in various scientific research settings, encompassing genetics, cancer biology, and collaborative research endeavors.

Jacob Higgins, Ph.D. completed their education from the University of Michigan where they obtained a Doctor of Philosophy (Ph.D.) degree in Human Genetics. Jacob pursued their Bachelor's Degree in Molecular and Cellular Biology from the University of Washington, where they attended from 1998 to 2004. Additional information about their education at the University of Washington, such as the degree name and field of study, is not provided.