Experimental Crisprx Platform Developer

About Us We are a biotechnology company based in San Francisco. We are using our in vivo drug discovery platform and  AI models trained on its data to uncover better drugs for more patients. Our Mosaic platform is the first to make in vivo data generation scalable, with single-cell precision, to capture in vivo context of disease at the first step of drug discovery and to better represent patient diversity in drug response over current in vitro assays. We are using Mosaic to build the world’s largest in vivo atlas of how drugs interact with patient cells and how they alter gene function in diverse biological contexts. We are using the unprecedented scale and sophistication of the data in this atlas to train single-cell foundation models that learn context dependency of gene function and help us find novel targets and drugs that are more likely to work in patients.

Your Role At Vevo, we generate a huge amount of data on how drugs interact with cells from many different patients, at a single-cell resolution and in an in-vivo context. From this data comes a large number of novel hypotheses and hits on potential new drug discovery programs. We are seeking an experienced CRISPRx screening scientist to help us execute screens at scale, deconvolve targets of novel bioactive molecules, and validate deconvolved targets in oncology programs. You will be part of our experimental team, with colleagues who are specialized in single-cell method development in oncology. You will also work closely with the bioinformatics team.

Qualifications - Required

• In-depth experience in having run CRISPRx screens for target deconvolution, ideally paired i/a or KO/a screening
• Experience in scaling screening operations and training others
• Experience in method development in the CRISPRx space whether combinatorial screening, Perturb/Crop-seq based screening, etc.
• Experience and familiarity with programming for CRISPR screen analysis
• Experience and familiarity in building out oncology stories by interpreting screen data, generating knockdown/out lines, and assessing efficacy using dose-response, in-vivo xenograft, and biochemical assays in an oncology setting
• Experience in a fast paced environment and ability to work quickly to achieve company goals
• Ph.D in relevant discipline required

Qualifications - Desirable

• Deep oncology research background
• Experience in taking drug candidates to IND
• Postdoc and industry experience are strongly desired

Key Responsibilities

• Lead and execute CRISPR screens at high-throughput at Vevo
• Scale and develop robust experimental/computational pipelines for conducting drug MOA deconvolution screens
• Validate targets discovered from screens using traditional oncology assays
• Develop new methods in the CRISPRx screening space in conjunction with Vevo’s proprietary Mosaic single-cell multiplexed platform

Benefits

• Unlimited Paid Time Off (PTO).
• Monthly Lunch budget
• One-time Office set up budget
• US Employees: HMO Kaiser Platinum and PPO Anthem Gold medical as well as vision and dental plans for both the employee and dependents.