Chris Chen

Chris Chen is a principal scientist in the biology department at Dyno Therapeutics. Before joining Dyno, Chris was an assistant director of research support at the Texas Biomedical Research Institute. Prior to that, Chris worked as a research scientist at Mayo Clinic and as a teaching assistant for the CORE6510 Molecular Mechanisms of Human Disease graduate level course. Chris' work at Mayo Clinic focused on studying the role of microRNAs in autosomal dominant polycystic kidney disease. Chris isolated urinary exosomes from human patients and controls, purified the microRNAs from the exosomes, and sequenced these microRNAs using MiSeq and HiSeq. This data was used to identify urine microRNA biomarkers in autosomal dominant polycystic kidney disease. In animal models, both urine exosome microRNAs and whole kidney microRNAs were isolated at pre-cystic time points. MicroRNAs were quantitated using microRNA microarray and results were analyzed by Ingenuity Pathway Analysis to identify a pre-cystic disease microRNA signature as well as elucidate possible mechanisms of cystogenesis.

Chris Chen has a Ph.D in the Department of Molecular and Human Genetics from Baylor College of Medicine. Chris also has a B.S. in Genetics from Purdue University. Chris attended Hunterdon Central Regional High School.